Cockcroft-Gault公式和中国人MDRD公式在红斑狼疮患者肾小球滤过率的评估

doi:10.3969/j.issn.1000-8535.2018.02.004

广州医药 ›› 2018, Vol. 49 ›› Issue (2): 15-18.DOI: 10.3969/j.issn.1000-8535.2018.02.004

Cockcroft-Gault公式和中国人MDRD公式在红斑狼疮患者肾小球滤过率的评估

关昌杰, 梁鸣, 陈敢, 李剑文, 何凤, 傅君舟

广州市第一人民医院肾内科(广州 510180)

收稿日期:2017-12-12 出版日期:2018-03-20 发布日期:2021-12-01
通讯作者: 傅君舟,E-mail:fujzhou@163.com
基金资助:
国家自然科学基金资助项目(81570689);广州市科技计划项目(201707010290)

Evaluation of glomerular filtration rate by Cockcroft-Gault equation and Chinese MDRD equation in patients with lupus

GUAN Changjie, LIANG Ming, CHEN Gan, LI Jianwen, HE Feng, FU Junzhou

Department of Nephrology, Guangzhou First People's Hospital,Guangzhou 510180,China

Received:2017-12-12 Online:2018-03-20 Published:2021-12-01

摘要/Abstract

摘要： 目的探讨Cockcroft-Gault公式(CG公式)以及中国人MDRD公式(c-MDRD)在狼疮(SLE)患者肾小球滤过率(GFR)评估中的作用。方法本研究纳入193名SLE患者。测量肾小球滤过率(mGFR)、血清肌酐(SCr),根据cMDRD公式,以及C-G公式分别得出估算肾小球滤过率(eGFR)。从不同方面对eGFR进行评估。结果 193名患者中, mGFR中位值为75.01 mL/(min·1.73 m²),eGFR-CG中位值70.22 mL/(min·1.73 m²),eGFR-cMDRD中位值70.67 mL/(min·1.73 m²)。患者分为mGFR≥60/(n=108)和mGFR<60 mL/(min·1.73 m²)(n=85)。对于总体病人而言, CG和 c-MDRD偏差值分别为0.64和3.91 mL/(min·1.73 m²)。在精确度以及准确度上,CG均优于c-MDRD。除了mGFR<60 mL/(min·1.73 m²)组中CG偏差值稍高于c-MDRD外,CG在分组后的表现仍然优于c-MDRD。结论和中国人MDRD公式相比,CG公式更加适合用在SLE的GFR评估。

关键词: 系统性红斑狼疮, 肾小球滤过率, 中国人MDRD公式, Cockcroft-Gault公式

Abstract: Objective Few studies has been conducted concerned Glomerular Filtration Rate(GFR) estimationequations about Cockcroft-Gault equation(CG equation)and Chinese Modification of Diet in Renal Disease equation(c-MDRD equation)in systemic lupus erythematosus(SLE). Our study aims to assess performance of two equations for renal function evaluation in patients with SLE.Methods 193 participants were enrolled in this study. Measured GFR was obtained by renal dynamic imaging method and Serum Creatinine (SCr)was determined for each participant. eGFR was gained by CG equation and c-MDRD equation respectively. Performance of equations were compared from different aspects.Results mGFR(median), eGFR-CG(median), eGFR-cMDRD(median)of the 193 participants were 75.01,70.22,70.67 mL/(min·1.73 m²)respectively. The participants were divided into two groups including mGFR≥60 (n=108)as well as mGFR<60 mL/(min·1.73 m²)(n=85). For overall participants, bias for CG equation and c-MDRD equation were 0.64, 3.91 mL/(min·1.73 m²) respectively. In terms of precision and accuracy, CG equation was better than c-MDRD equation. In subgroup, CG equation was still superior to c-MDRD equation except for bias in CG equation which is higher than c-MDRD equation in mGFR<60 ml(min·1.73 m²).Conclusion Compared with c-MDRD equation, CG performed better in GFR estimation in patients with SLE.

Key words: Systemic lupus erythematosus, Glomerular filtration rate, Modification of Diet in Renal Disease equation, Cockcroft-Gault equation

关昌杰, 梁鸣, 陈敢, 李剑文, 何凤, 傅君舟. Cockcroft-Gault公式和中国人MDRD公式在红斑狼疮患者肾小球滤过率的评估[J]. 广州医药, 2018, 49(2): 15-18.

GUAN Changjie, LIANG Ming, CHEN Gan, LI Jianwen, HE Feng, FU Junzhou. Evaluation of glomerular filtration rate by Cockcroft-Gault equation and Chinese MDRD equation in patients with lupus[J]. Guangzhou Medical Journal, 2018, 49(2): 15-18.

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Cockcroft-Gault公式和中国人MDRD公式在红斑狼疮患者肾小球滤过率的评估

Evaluation of glomerular filtration rate by Cockcroft-Gault equation and Chinese MDRD equation in patients with lupus

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