微泡增强的超声空化对荷瘤兔乳腺癌作用效果的研究

doi:10.3969/j.issn.1000-8535.2016.02.011

广州医药 ›› 2016, Vol. 47 ›› Issue (2): 32-34.DOI: 10.3969/j.issn.1000-8535.2016.02.011

微泡增强的超声空化对荷瘤兔乳腺癌作用效果的研究

位红芹, 余美玲, 韦英丽, 肖妮娜, 柳建华

广州医科大学附属广州市第一人民医院超声科(广州 510180)

收稿日期:2016-01-22 出版日期:2016-03-20 发布日期:2021-11-30
通讯作者: 柳建华,E-mai:liujianhua666666@163.com
基金资助:
广州市医药卫生科技项目(20131A011001);广东省自然科学基金面上项目(S2013010016277);广东省公益研究与能力建设专项资金项目(2014A020212014)

Experimental study of the effect using microbubbles-enhanced ultrasound cavitation on VX2 breast tumor in rabbits

Wei Hongqin, Yu Meiling, Wei Yingli, et al

Department of Ultrasound, Guangzhou First People's Hospital Affiliated to Guangzhou Medical University,Guangzhou 510180,China

Received:2016-01-22 Online:2016-03-20 Published:2021-11-30

摘要/Abstract

摘要： 目的探讨微泡增强的超声空化对荷瘤兔乳腺癌的治疗效果。方法建立兔VX2乳腺癌模型,肿瘤兔随机分成两组,超声微泡组及单纯超声组,各组于治疗前及治疗后分别行超声造影,分析造影前后肿瘤灌注情况。结果超声微泡组治疗前后造影灰阶值改变明显,造影灰阶值从治疗前的(20.26±2.59)降至(3.71±1.61)(P<0.01);而单纯超声组肿瘤造影灰阶值无明显统计学差异(P>0.05)。结论微泡增强的超声空化对荷瘤兔乳腺癌有一定的治疗效果。

关键词: 超声空化, 微泡, 乳腺癌

Abstract: Objective To investigate the treatment effect of microbubbles-enhanced ultrasound cavitation on VX2 breast tumor in rabbits. Methods The rabbit model of VX2 breast tumor were established. The rabbits were randomly divided into two groups, microbubbles-enhanced ultrasound (US+MBs) group and standard ultrasound (US) group. The VX2 breast tumor perfusion were imaged and assessed using contrast enhanced ultrasonography (CUES) before and after treatment. Results The contrast enhanced grayscale value (GSV) of VX2 breast tumors decreased significantly in the US+MBs group, from 20.26±0.59(before treatment) to 3.71±.761 (after treatment)(P<0.01). While there was no significance of GSV before and after treatment (P>0.05) in the US group. Conclusion Microbubble-enhancement ultrasound cavitation has a certain therapeutic effect on the VX2 breast tumor in rabbits.

Key words: Ultrasound cavitation, Microbubbles, Breast tumor

位红芹, 余美玲, 韦英丽, 肖妮娜, 柳建华. 微泡增强的超声空化对荷瘤兔乳腺癌作用效果的研究[J]. 广州医药, 2016, 47(2): 32-34.

Wei Hongqin, Yu Meiling, Wei Yingli, et al. Experimental study of the effect using microbubbles-enhanced ultrasound cavitation on VX2 breast tumor in rabbits[J]. Guangzhou Medical Journal, 2016, 47(2): 32-34.

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微泡增强的超声空化对荷瘤兔乳腺癌作用效果的研究

Experimental study of the effect using microbubbles-enhanced ultrasound cavitation on VX2 breast tumor in rabbits

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