黏附因子E-cadherin和TLR9在系统性红斑狼疮发病机制中的作用

doi:10.3969/j.issn.1000-8535.2018.05.002

广州医药 ›› 2018, Vol. 49 ›› Issue (5): 5-8.DOI: 10.3969/j.issn.1000-8535.2018.05.002

黏附因子E-cadherin和TLR9在系统性红斑狼疮发病机制中的作用

刘慧敏¹, 李改静², 李小兵², 高亚莹²

1 河北工程大学附属医院(邯郸 056000);
2 河北工程大学(邯郸 056038)

收稿日期:2018-05-10 出版日期:2018-09-20 发布日期:2021-11-29
通讯作者: 刘慧敏,E-mail:1836032295@qq.com
基金资助:
邯郸市科技局项目(1623208061)

Effect of adhesion molecule E-cadherin and TLR9 in the pathogenesis of systemic lupus erythematosus

LIU Huimin¹, LI Gaijing², LI Xiaobing², GAO Yaying²

1 Affiliated Hospital of Hebei University of Engineering,Handan 056000, China;
2 Hebei University of Engineering, Handan 056038,China

Received:2018-05-10 Online:2018-09-20 Published:2021-11-29

摘要/Abstract

摘要： 目的探讨黏附因子E-钙粘蛋白(E-cadherin)和Toll样受体9(TLR9)在系统性红斑狼疮(SLE)发病机制中的作用。方法随机选取SLE患者41例,健康对照组18例,采用酶联免疫吸附试验(ELISA)法检测血清中sE-cadherin的表达,采用流式细胞技术(FCM)检测外周血单核细胞上TLR9的表达。分析 sE-cadherin,TLR9与系统性红斑狼疮患者病情的活动性。结果 SLE组血清中sE-cadherin的表达水平高于正常组(P=0.00),差异有统计学意义;SLE活动组血清中sE-cadherin表达水平高于稳定组(P=0.06),但差异无统计学意义;SLE组TLR9表达高于健康组(P=0.00),活动组高于稳定期组(P=0.00),差异均有统计学意义;SLE患者TLR9表达与SLEDI呈正相关(r=0.727,P=0.00),差异有统计学意义。结论血清中sE-cadherin和外周血单核细胞内TLR9均参与了SLE患者病情发展的过程,并且二者在SLE发病机制中可能具有协调作用。

关键词: 系统性红斑狼疮, 可溶性黏附因子E-cadherin, Toll样受体9

Abstract: Objective To explore the effect of adhesion molecule E-cadherin and Toll-like receptor-9(TLR9) in the pathogenesis of systemic lupus erythematosus(SLE). Methods 41 patients with SLE and 18 healthy controls were selected randomly.Expression of TLR9 in peripheral blood mononuclear cells determined by FCM. SE-cadherin levels were measured in the serum by ELISA analysis. The correlation between sE-cadherin、TLR9 and the patient's condition of SLE was analyzed. Results Compared with healthy subjects,the expression of sE-cadherin in serum was higher among SLE patients(P=0.00),there was statistically significant between two groups;activity group was higher than inactivity group and healthy controls(P=0.06),but there was no statistically significant between activity group and inactivity group. Compared with healthy subjects,the expression of TLR9 in peripherql blood mononuclear cells was higher among SLE patients(P=0.00);activity group was higher than inactivity group(P=0.00),there was all statistically significant between two groups.The positive correlation was observed between TLR9 expression levels and clinical measure of the SLEDAI(r=0.727,P=0.00),there was statistically significant between two groups. Conclusion SE-cadherin and TLR9 may play an important role in SLE,and may interact with each other which needed further study.

Key words: Systemic lupus erythematosus, Soluble E-cadherin, Toll-like receptor-9(TLR9)

刘慧敏, 李改静, 李小兵, 高亚莹. 黏附因子E-cadherin和TLR9在系统性红斑狼疮发病机制中的作用[J]. 广州医药, 2018, 49(5): 5-8.

LIU Huimin, LI Gaijing, LI Xiaobing, GAO Yaying. Effect of adhesion molecule E-cadherin and TLR9 in the pathogenesis of systemic lupus erythematosus[J]. Guangzhou Medical Journal, 2018, 49(5): 5-8.

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黏附因子E-cadherin和TLR9在系统性红斑狼疮发病机制中的作用

Effect of adhesion molecule E-cadherin and TLR9 in the pathogenesis of systemic lupus erythematosus

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