达泊西汀联合达克罗宁胶浆治疗早泄的临床研究

doi:10.20223/j.cnki.1000-8535.2025.04.013

广州医药 ›› 2025, Vol. 56 ›› Issue (4): 523-528.DOI: 10.20223/j.cnki.1000-8535.2025.04.013

达泊西汀联合达克罗宁胶浆治疗早泄的临床研究

张同殿¹, 谢明亮¹, 赵守国¹, 候方方¹, 郭丙毅¹, 孔佳²

1 聊城市人民医院男科（山东聊城 252000）
2 聊城市人民医院肾内科（山东聊城 252000）

收稿日期:2024-04-18 出版日期:2025-04-20 发布日期:2025-05-07
通讯作者: 孔佳,E-mail：694527119@qq.com

Clinical study on the treatment of premature ejaculation with dapoxetine combined with dacronine mucilage

ZHANG Tongdian¹, XIE Mingliang¹, ZHAO Shouguo¹, HOU Fangfang¹, GUO Bingyi¹, KONG Jia²

1 Department of Andrology,Liaocheng People’s Hospital,Liaocheng 252000,China
2 Department of Nephrology,Liaocheng People’s Hospital,Liaocheng 252000,China

Received:2024-04-18 Online:2025-04-20 Published:2025-05-07

摘要/Abstract

摘要： 目的探讨盐酸达泊西汀联合达克罗宁胶浆治疗早泄的临床疗效。方法选取男科门诊146例早泄患者,随机分组,对照组服用达泊西汀片,研究组为达泊西汀片和达克罗宁胶浆联合治疗,再将研究组分为阴茎头敏感度高组和敏感度正常组,记录各组治疗前、治疗8周后早泄相关指标。结果治疗后对照组阴道内射精潜伏期（IELT）、早泄诊断量表（PEDT）和早泄指数量表（IPE）中Q6+Q7分别为（4.68±2.79）、（9.52±2.14）、（6.48±1.30）,研究组IELT、PEDT和Q6+Q7分别为（6.09±3.09）、（7.52±1.92）、（7.85±1.36）,各组相关指标均较治疗前改善（P<0.05）,研究组各指标改善程度优于对照组（P<0.05）;治疗后敏感度高组IELT、PEDT和Q6+Q7分别为（6.76±2.99）、（6.84±1.53）、（8.16±1.10）,敏感度正常组IELT、PEDT和Q6+Q7分别为（5.13±3.02）、（8.50±2.03）、（7.40±1.59）,敏感度高组各指标改善程度优于敏感度正常组（P<0.05）;对照组、研究组总有效率分别为69.86%（51/73）、84.93%（62/73）,研究组治疗效果优于对照组（P<0.05）;敏感度高组、敏感度正常组总有效率分别为93.02%（40/43）、73.33（22/30）,敏感度高组治疗效果优于敏感度正常组（P<0.05）。结论达泊西汀联合达克罗宁胶浆治疗早泄效果显著,阴茎头敏感患者联合达克罗宁胶浆治疗受益更大。

关键词: 盐酸达泊西汀, 达克罗宁胶浆, 阴茎头敏感度, 早泄

Abstract: Objective To investigate the clinical efficacy of dapoxetine hydrochloride combined with dclonine mucilage in the treatment of premature ejaculation．Methods A total of 146 patients from andrology department with premature ejaculation were selected and randomly divided into control group and research group．The control group was treated with dapoxetine alone,while the research group was treated with dapoxetine combined with dacronine mucilage．The research group was divided into high sensitivity group and normal sensitivity group．The indexes related to premature ejaculation were recorded before treatment and 8 weeks after treatment．Results After treatment,intravaginal ejaculatory latency time（IELT）,Premature Ejaculation Diagnosis Tool（PEDT）and Q6+Q7 of the index of premature ejaculation（IPE）in control group were（4.68±2.79）,（9.52±2.14） and （6.48±1.30）,respectively,while IELT,PEDT and Q6+Q7 in research group were（6.09±3.09）,（7.52±1.92） and （7.85±1.36）,respectively．The relevant indexes in all groups were significantly improved compared with those before treatment（P<0.05）,and the improvement of all indexes in research group was better than that in control group（P<0.05）．After treatment,IELT,PEDT and Q6+Q7 in the highly sensitivity group were（6.76±2.99）,（6.84±1.53）and（8.16±1.10）,respectively,while IELT,PEDT and Q6+Q7 in the normal sensitivity group were（5.13±3.02）,（8.50±2.03）and（7.40±1.59）,respectively．The improvement of all indexes in the high sensitivity group was better than that in the normal sensitivity group（P<0.05）．The total effective rate of the control group and the research group was 69.86%（51/73）and 84.93%（62/73）,respectively．The therapeutic effect of the research group was significantly better than that of the control group（P<0.05）．The total effective rate of the high sensitivity group and the normal sensitivity group was 93.02%（40/43）and 73.33%（22/30）,respectively．The therapeutic effect of the high sensitivity group was significantly better than that of the normal sensitivity group（P<0.05）．Conclusions Dapoxetine combined with dacronine mucilage has significant effect in the treatment of premature ejaculation,and the patients with high sensitivity of penile head will benefit more from combined dacronine mucilage therapy．

Key words: dapoxetine, dacronine mucilage, sensitivity of penile head, premature ejaculation

张同殿, 谢明亮, 赵守国, 候方方, 郭丙毅, 孔佳. 达泊西汀联合达克罗宁胶浆治疗早泄的临床研究[J]. 广州医药, 2025, 56(4): 523-528.

ZHANG Tongdian, XIE Mingliang, ZHAO Shouguo, HOU Fangfang, GUO Bingyi, KONG Jia. Clinical study on the treatment of premature ejaculation with dapoxetine combined with dacronine mucilage[J]. Guangzhou Medical Journal, 2025, 56(4): 523-528.

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达泊西汀联合达克罗宁胶浆治疗早泄的临床研究

Clinical study on the treatment of premature ejaculation with dapoxetine combined with dacronine mucilage

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