复方甘草酸苷联合卡泊三醇乳膏治疗寻常型银屑病的效果观察

doi:10.20223/j.cnki.1000-8535.2024.10.012

摘要/Abstract

摘要： 目的探讨复方甘草酸苷联合卡泊三醇乳膏治疗寻常型银屑病的效果观察。方法选取辽健集团阜新矿总医院2019年12月—2022年12月收治的96例寻常型银屑病患者,分为联合组与对照组,每组48例。对照组使用卡泊三醇乳膏治疗,联合组在对照组基础上联用复方甘草酸苷治疗,对比临床疗效,以皮质含量、经表皮水分流失（TEWL）、角质层水含量变化评价患者的皮肤屏障功能,并对比两组患者治疗前后T细胞相关炎症因子表达水平。结果联合组治疗总有效率较对照组高[93.75% vs 77.08%,χ²=5.352,P=0.021];治疗后两组皮质含量、角质层水含量升高,联合组高于对照组,TEWL降低,联合组低于对照组[皮质含量：（73.59±7.24）μg/cm² vs（110.12±13.64）μg/cm²,t=16.389,P<0.001;角质层水含量：（25.28±3.25）% vs（16.24±2.14）%,t=16.095,P<0.001;TEWL：（8.06±1.44）g/（h·m²）vs（11.71±2.68）g/（h·m²）,t=8.312,P<0.001];治疗后两组患者白细胞介素-2（IL-2）、白细胞介素-6（IL-6）、γ干扰素（IFN-γ）表达水平均降低,且联合组低于对照组[IL-2：（22.25±3.32）vs（26.62±3.24）pg/mL,t=6.661,P<0.001;IL-6：（80.46±5.11）vs（112.62±12.16）pg/mL,t=16.892,P<0.001;IFN-γ：（68.62±10.73）vs（51.26±6.37）ng/L,t=9.639,P<0.001]。结论复方甘草酸苷联合卡泊三醇乳膏可改善寻常型银屑病皮肤屏障功能,降低炎症因子,改善Th1/Th2细胞因子失衡情况。

关键词: 复方甘草酸苷, 卡泊三醇乳膏, 寻常型银屑病

Abstract: Objective To investigate the effect of compound glycyrrhizin and caspotriol cream in psoriasis vulgaris. Methods The 96 psoriasis patients admitted to Fuxin Mine General Hospital from December 2019 to December 2022 were selected and divided into combined group and control group,with 48 patients in each group．The control group was treated with caspotriol cream,the combined group treated with compound glycyrrhizin treatment,the clinical efficacy was compared,and the skin barrier function of patients was evaluated by cortical content,transepidermal water loss（TEWL）,and changes in stratum corneum water content．The expression levels of T cell related inflammatory factors before and after treatment were compared between the two groups. Results The overall effective treatment rate in the combined group was higher than in the control group[93.75% vs 77.08%,χ²=5.352,P=0.021]．After treatment,cortical and stratum corneum water levels increased in both groups,with the combined group being higher than the control group．TEWL decreased and the combined group was lower than the control group[cortical content：（73.59±7.24）μg/cm² vs（110.12±13.64）μg/cm²,t=16.389,P<0.001;water content in the stratum corneum：（25.28±3.25）% vs（16.24±2.14）%,t=16.095,P<0.001;TEWL：（8.06±1.44）g/（h·m²）vs（11.71±2.68）g/（h·m²）,t=8.312,P<0.001]．After treatment,two groups of patients were treated with interleukin-2（IL-2）,interleukin-6（IL-6） and interferon（IFN）-γ,and the combined group was lower than the control group[IL-2：（22.25±3.32）pg/mL vs（26.62±3.24）pg/mL,t=6.661,P<0.001;IL-6：（80.46±5.11）pg/mL vs（112.62±12.16）pg/mL,t=16.892,P<0.001;IFN-γ：（68.62±10.73）ng/L vs（51.26±6.37）ng/L,t=9.639,P<0.001]. Conclusions The combination of compound glycyrrhizin and carpotriol cream can improve the skin barrier function of psoriasis vulgaris,reduce inflammatory factors,and improve the imbalance of Th1/Th2 cytokines．

Key words: compound glycyrrhetinic acid glycoside, capotriol cream, psoriasis vulgaris

马雪姣, 聂丽, 沈路路, 王环, 黄宽, 姜永刚. 复方甘草酸苷联合卡泊三醇乳膏治疗寻常型银屑病的效果观察[J]. 广州医药, 2024, 55(10): 1172-1176.

MA Xuejiao, NIE Li, SHEN Lulu, WANG Huan, HUANG Kuan, JIANG Yonggang. The effect of compound glycyrrhizin and caspotriol cream in treating psoriasis vulgaris[J]. Guangzhou Medical Journal, 2024, 55(10): 1172-1176.

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