兔VX2移植瘤内间质液压的分布异质性

doi:10.3969/j.issn.1000-8535.2023.12.004

摘要/Abstract

摘要： 目的探索实体肿瘤内部不同区域的间质液压（IFP）分布的异质性。方法通过建立新西兰大白兔的皮下浅肌层VX2移植瘤模型,通过超声造影观察肿瘤的大小、形状、血流灌注等成瘤情况,并在超声引导下通过针芯法（WIN法）测量41只荷瘤兔VX2移植瘤内部不同区域的IFP。结果 41只荷瘤兔的VX2移植瘤的中央IFP为（23.79±8.07） mmHg、肿瘤外周1/2IFP为（15.58±5.22）mmHg、肿瘤外周1/4IFP为（8.29±5.47）mmHg,IFP从中央到外周逐步降低（F=70.85,P<0.001）。结论 VX2移植瘤内不同区域的IFP存在异质性,即从中央到外周IFP呈梯度显著降低。

关键词: VX2移植瘤, 超声, 针芯法, 间质液压, 异质性

Abstract: Objective To explore the heterogeneity of interstitial fluid pressure（IFP）distribution in different regions of solid tumors．Methods The model of VX2 tumor was established in New Zealand white rabbits．The size,shape and blood perfusion of the tumor were observed by contrast-enhanced ultrasound,the IFP of VX2 tumor in 41 rabbits was measured by the wick-in-needle method（WIN method）under the guidance of ultrasound．Results The mean values of central IFP,peripheral 1/2 IFP and peripheral 1/4 IFP were（23.79±8.07） mmHg,（15.58±5.22 ）mmHg and （8.29±5.47） mmHg,respectively by statistical analysis,the IFP values changed significantly with different regions（F=70.85,P<0.001）．Conclusions There is heterogeneity of IFP in different regions of VX2 xenografts,that is,from the center to the periphery,the IFP decreased significantly．

Key words: VX2 transplanted tumor, ultrasound, WIN method, interstitial fluid pressure, heterogeneity

陈丽萍, 柳建华, 黎昱材, 陈俏利, 何杨成, 冯玉仪, 翁沛华, 胡志文. 兔VX2移植瘤内间质液压的分布异质性[J]. 广州医药, 2023, 54(12): 26-31.

CHEN Liping, LIU Jianhua, LI Yucai, CHEN Qiaoli, HE Yangcheng, FENG Yuyi, WENG Peihua, HU Zhiwen. Heterogeneity of interstitial fluid pressure distribution in VX2 xenografts of rabbits[J]. Guangzhou Medical Journal, 2023, 54(12): 26-31.

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