丙酸睾酮注射液联合乌司他丁对脓毒症患者免疫失衡的调节作用

doi:10.3969/j.issn.1000-8535.2022.06.011

广州医药 ›› 2022, Vol. 53 ›› Issue (6): 52-55.DOI: 10.3969/j.issn.1000-8535.2022.06.011

丙酸睾酮注射液联合乌司他丁对脓毒症患者免疫失衡的调节作用

张昊杰, 李京

南阳市第一人民医院急诊科 (南阳 47300)

收稿日期:2021-10-21 出版日期:2022-11-20 发布日期:2022-11-30

Regulatory effect of testosterone propionate injection combined with ulinastatin on immune imbalance in patients with sepsis

ZHANG Haojie, LI Jing

Emergency Department,Nanyang First People's Hospital,Nanyang 47300,China

Received:2021-10-21 Online:2022-11-20 Published:2022-11-30

摘要/Abstract

摘要： 目的探讨丙酸睾酮注射液联合乌司他丁对脓毒症患者免疫失衡的调节作用。方法选取我院2019年10月—2020年1月收治的88例脓毒症患者,随机分成观察组和对照组各44例,对照组采用乌司他丁配合常规治疗,观察组在此基础上联合丙酸睾酮注射液对患者治疗,比较治疗1周2组临床疗效差异,观察治疗前及治疗1周,2组炎症因子水平[白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、白细胞介素-1β(IL-1β)]、睾酮(T)、白蛋白(Alb)水平及疾病危重程度(APACHEⅡ评分)、器官衰竭程度(SOFA评分)变化,分析治疗1周内2组患者药物不良反应发生情况差异。结果治疗1周,观察组总有效率高于对照组(P＜0.05);2组患者IL-6、IL-1β水平及APACHEⅡ、SOFA评分均降低,且观察组较对照组更低(P＜0.05);2组患者IL-10、T、Alb水平均升高,且观察组较对照组更高(P＜0.05);2组药物不良反应总发生率比较无统计学意义(P>0.05)。结论丙酸睾酮注射液联合乌司他丁治疗脓毒症可取得良好临床疗效,可有效改善病情及预后,对患者免疫失衡调节有积极意义。

关键词: 丙酸睾酮, 乌司他丁, 脓毒症

Abstract: Objective To investigate the regulatory effect of testosterone propionate injection combined with ulinastatin on immune imbalance in patients with sepsis.Methods A total of 88 patients with sepsis treated in our hospital from October 2019 to January 2020 were randomly divided into observation group and control group,with 44 cases each.The control group was treated with ulinastatin combined with routine treatment,while the observation group was treated with testosterone propionate injection additionally.The clinical efficacy difference between the two groups were compared after treating 1 week.The levels of inflammatory factors [interleukin-6 (IL-6),interleukin-10 (IL-10),interleukin-1 β (IL-1β)],testosterone (T),albumin (Alb),the severity of disease (APACHE II score) and the degree of organ failure (SOFA score) in the two groups were observed before and 1 week after treatment.The differences of adverse drug reactions between the two groups within 1 week of treatment were analyzed.Results The total effective rate of the observation group was higher than that of the control group (P＜0.05).IL-6 and IL-1β levels and APACHE II and SOFA scores decreased after treatment,while those of the observation group were lower than the control group (P＜0.05).The levels of IL-10,T and Alb in the two groups were increased,while those in the observation group were higher than the control group (P ＜ 0.05); the total incidence of adverse drug reactions in the two groups was not statistically significant (P>0.05).Conclusions Testosterone propionate injection combined with ulinastatin had good clinical efficacy in the treatment of sepsis,effectively improved the condition and prognosis,and had positive significance in the regulation of immune imbalance.

Key words: testosterone propionate, ulinastatin, sepsis

张昊杰, 李京. 丙酸睾酮注射液联合乌司他丁对脓毒症患者免疫失衡的调节作用[J]. 广州医药, 2022, 53(6): 52-55.

ZHANG Haojie, LI Jing. Regulatory effect of testosterone propionate injection combined with ulinastatin on immune imbalance in patients with sepsis[J]. Guangzhou Medical Journal, 2022, 53(6): 52-55.

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丙酸睾酮注射液联合乌司他丁对脓毒症患者免疫失衡的调节作用

Regulatory effect of testosterone propionate injection combined with ulinastatin on immune imbalance in patients with sepsis

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