自适应调强放疗同步铂类化疗治疗局部晚期宫颈癌患者的可行性分析

doi:10.3969/j.issn.1000-8535.2022.05.019

广州医药 ›› 2022, Vol. 53 ›› Issue (5): 93-96.DOI: 10.3969/j.issn.1000-8535.2022.05.019

自适应调强放疗同步铂类化疗治疗局部晚期宫颈癌患者的可行性分析

杨晓, 杨云, 连烨

南阳市第一人民医院放射肿瘤科 (南阳 473000)

收稿日期:2021-08-19 出版日期:2022-09-20 发布日期:2022-10-11

Feasibility analysis of adaptive intensity modulated radiotherapy combined with platinum-based chemotherapy in the treatment of local advanced cervical cancer

YANG Xiao, YANG Yun, LIAN Ye

Radiation Oncology Department,Nanyang First People's Hospital,Nanyang 473000,China

Received:2021-08-19 Online:2022-09-20 Published:2022-10-11

摘要/Abstract

摘要： 目的研究自适应调强放疗(ART)同步铂类化疗治疗局部晚期宫颈癌患者的可行性。方法选取我院诊治的92例局部晚期宫颈癌患者,随机分为研究组与对照组各46例,其中对照组行调强放疗(IMRT)同步铂类化疗,研究组行ART同步铂类化疗。治疗8周后,比较2组患者临床疗效;于治疗前后比较2组患者肿瘤标志物[癌胚抗原(CEA)、鳞状细胞癌抗原(SCC-Ag)]水平;以急性放射损伤分级标准(RTOG)和常见不良反应事件评价标准(CTCAE)比较2组患者不良反应发生情况。结果治疗8周后,研究组客观缓解率高于对照组(P＜0.05);2组患者CEA、SCC-Ag水平均较治疗前降低,且研究组低于对照组 (P＜0.05);研究组基于RTOG的消化道反应等级与泌尿系统反应等级均低于对照组(P＜0.05);2组患者基于CTCAE的肝功能损害与皮疹评级相比,差异无统计学意义(P＞0.05)。结论 ART同步铂类化疗治疗局部晚期宫颈癌患者疗效较好,使患者病情好转,同时安全性突出,切实可行。

关键词: 自适应调强放疗, 铂类化疗, 局部晚期宫颈癌

Abstract: Objective To study the feasibility of adaptive radiotherapy (ART) combined with platinum chemotherapy in the treatment of locally advanced cervical cancer. Methods A total of 92 patients with locally advanced cervical cancer treated in our hospital were randomly divided into study group and control group, with 46 cases in each group. The control group received intensity-modulated radiation therapy (IMRT) combined with platinum chemotherapy and the study group received ART combined with platinum chemotherapy. After 8 weeks of treatment, the clinical effects of the two groups were compared. The levels of tumor markers [carcinoembryonic antigen (CEA) and squamous cell carcinoma associated antigen (SCC-Ag)] were compared between the two groups before and after treatment. The incidence of adverse reactions in the two groups was compared with the grading standard of Acute Radiation Injury Group (RTOG) and Common Terminology Criteria for Adverse Events (CTCAE). Results After 8 weeks of treatment, the Objective remission rate in the study group was higher than that in the control group (P<0.05). The levels of CEA and SCC-Ag in the study group were significantly lower than those in the control group (P<0.05). The reaction grades of digestive tract and urinary system based on RTOG in the study group were significantly lower than those in the control group (P<0.05). There was no significant difference in CTCAE based liver function impairment and rash rating between the two groups (P> 0.05). Conclusions ART combined with platinum chemotherapy is effective and safe in the treatment of locally advanced cervical cancer.

Key words: adaptive radiotherapy, platinum chemotherapy, local advanced cervical cancer

杨晓, 杨云, 连烨. 自适应调强放疗同步铂类化疗治疗局部晚期宫颈癌患者的可行性分析[J]. 广州医药, 2022, 53(5): 93-96.

YANG Xiao, YANG Yun, LIAN Ye. Feasibility analysis of adaptive intensity modulated radiotherapy combined with platinum-based chemotherapy in the treatment of local advanced cervical cancer[J]. Guangzhou Medical Journal, 2022, 53(5): 93-96.

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自适应调强放疗同步铂类化疗治疗局部晚期宫颈癌患者的可行性分析

Feasibility analysis of adaptive intensity modulated radiotherapy combined with platinum-based chemotherapy in the treatment of local advanced cervical cancer

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