免疫球蛋白联合甲泼尼龙疗法对自身免疫性脑炎患者T淋巴细胞亚群、免疫球蛋白、IL-6和CXC13水平影响

doi:10.3969/j.issn.1000-8535.2021.02.020

广州医药 ›› 2021, Vol. 52 ›› Issue (2): 84-88.DOI: 10.3969/j.issn.1000-8535.2021.02.020

免疫球蛋白联合甲泼尼龙疗法对自身免疫性脑炎患者T淋巴细胞亚群、免疫球蛋白、IL-6和CXC13水平影响

方雅秀, 郑东, 谭燕, 周晓明, 陈国华, 章慧, 郭彩凤

广州医科大学附属脑科医院神经内科(广州 510370)

收稿日期:2020-09-27 出版日期:2021-03-20 发布日期:2021-11-25
基金资助:
广东省自然科学基金-基础与应用基础研究基金项目(2019A1515011611)

Effect of immunoglobulin combined with methylprednisolone on T lymphocyte subsets, immunoglobulin, IL-6 and CXC13 levels in patients with autoimmune encephalitis

FANG Yaxiu, ZHENG Dong, TAN Yan, ZHOU Xiaoming, CHEN Guohua, ZHANG Hui, GUO Caifeng

Department of Neurology, Brain Hospital Affiliated to Guangzhou Medical University,Guangzhou 510370,China

Received:2020-09-27 Online:2021-03-20 Published:2021-11-25

摘要/Abstract

摘要： 目的观察免疫球蛋白联合甲泼尼龙疗法对自身免疫性脑炎患者T淋巴细胞亚群、免疫球蛋白、白介素-6(IL-6)和CXC趋化因子13(CXC13)水平影响。方法选取2017年1月—2020年3月本院收治的60例自身免疫性脑炎患者,采用随机数字表法分为观察组30例与对照组30例。对照组给予甲泼尼龙疗法,观察组在对照组结合免疫球蛋白治疗。两组均以4周后评价。比较两组疗效,治疗前后T淋巴细胞亚群、免疫球蛋白、IL-6、CXC13及简易智能精神状态检查量表(MMSE)变化。结果观察组总有效率(83.33%)高于对照组(60.00%)(P<0.05)。观察组治疗后CD⁺₃、CD⁺₄和CD⁺₄/CD⁺₈高于对照组(P<0.05)。观察组治疗后血清IgA、IgG和IgM水平低于对照组(P<0.05)。观察组治疗后血清IL-6和CXC13水平低于对照组(P<0.05)。观察组治疗后MMSE评分高于对照组(P<0.05)。结论免疫球蛋白联合甲泼尼龙疗法对自身免疫性脑炎患者疗效良好,且可增强机体细胞和体液免疫功能,降低IL-6和CXC13水平。

关键词: 免疫球蛋白, 甲泼尼龙疗法, 自身免疫性脑炎, T淋巴细胞亚群, 免疫球蛋白, 白介素-6, CXC趋化因子13

Abstract: Objective To observe the effect of immunoglobulin combined with methylprednisolone on T lymphocyte subsets, immunoglobulin, interleukin-6 (IL-6) and CXC chemokine 13 (CXC13) in patients with autoimmune encephalitis. Methods 60 patients with autoimmune encephalitis admitted to our hospital from January 2017 to March 2020 were divided into 30 cases of observation group and 30 cases of control group. The control group was treated with methylprednisolone, and observation group was treated with immunoglobulin compared with the control group. The course of treatment in both groups was 4 weeks. The effects of the two groups were compared. The changes of T lymphocyte subsets, immunoglobulin, IL-6, CXC13 and MMSE before and after treatment were compared. Results Total effective rate (83.33%) of the observation group was higher than that of control group (60.00%) (P<0.05). After treatment, in the observation group, CD⁺₃, CD⁺₄ and CD⁺₄/CD⁺₈ were higher than that of control group (P<0.05); levels of serum IgA, IgG and IgM were lower than that of control group (P<0.05); serum levels of IL-6 and CXC13 were lower than that of control group (P<0.05); MMSE score was higher than that of control group (P<0.05). Conclusion Immunoglobulin combined with methylprednisolone is effective in the treatment of autoimmune encephalitis. It may enhance the cellular and humoral immune function, and reduce the levels of IL-6 and CXC13.

Key words: Immunoglobulin, Methylprednisolone therapy, Autoimmune encephalitis, T lymphocyte subsets, Immunoglobulin, Interleukin-6, CXC chemokine 13

方雅秀, 郑东, 谭燕, 周晓明, 陈国华, 章慧, 郭彩凤. 免疫球蛋白联合甲泼尼龙疗法对自身免疫性脑炎患者T淋巴细胞亚群、免疫球蛋白、IL-6和CXC13水平影响[J]. 广州医药, 2021, 52(2): 84-88.

FANG Yaxiu, ZHENG Dong, TAN Yan, ZHOU Xiaoming, CHEN Guohua, ZHANG Hui, GUO Caifeng. Effect of immunoglobulin combined with methylprednisolone on T lymphocyte subsets, immunoglobulin, IL-6 and CXC13 levels in patients with autoimmune encephalitis[J]. Guangzhou Medical Journal, 2021, 52(2): 84-88.

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免疫球蛋白联合甲泼尼龙疗法对自身免疫性脑炎患者T淋巴细胞亚群、免疫球蛋白、IL-6和CXC13水平影响

Effect of immunoglobulin combined with methylprednisolone on T lymphocyte subsets, immunoglobulin, IL-6 and CXC13 levels in patients with autoimmune encephalitis

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