盐酸普萘洛尔凝胶外涂治疗婴幼儿浅表性血管瘤的疗效及安全性

doi:10.3969/j.issn.1000-8535.2017.06.012

广州医药 ›› 2017, Vol. 48 ›› Issue (6): 40-42.DOI: 10.3969/j.issn.1000-8535.2017.06.012

盐酸普萘洛尔凝胶外涂治疗婴幼儿浅表性血管瘤的疗效及安全性

朱婉灵¹, 谭淑娟²

1 东莞市莞城医院(东莞 523000)
2 东莞市妇幼保健院(东莞 523000)

收稿日期:2017-07-19 发布日期:2021-12-01

Efficacy and safety of Propranolol hydrochloride gel in the external application treatment on superficial hemangioma in infants

ZHU Wanling¹, TAN Shujuan²

1 Dongguan Guancheng Hospital, Dongguan 523000,China
2 Dongguan Maternal and Child Health Care Hospital,Dongguan 523000,China

Received:2017-07-19 Published:2021-12-01

摘要/Abstract

摘要： 目的探讨盐酸普萘洛尔凝胶外涂治疗婴幼儿浅表性血管瘤的疗效及安全性。方法选取我院2015年5月—2017年5月收治的60例患有浅表性血管瘤的婴幼儿为研究对象,随机分为观察组和对照组,各30例。对照组口服盐酸普萘洛尔片治疗,观察组采用质量浓度为5 g/L的(20 g∶100 mg)盐酸普萘洛尔凝胶外涂方法治疗,疗程3个月。观察两组患者治疗效果及不良反应情况。结果治疗后,采用Achauer评定疗效,观察组Ⅰ级患儿1例,Ⅱ级患儿6例,Ⅲ级患儿12例,Ⅳ级患儿8例,Ⅴ级患儿3例,总有效率为96.67%(29/30),对照组Ⅰ级、Ⅱ级、Ⅲ级、Ⅳ级、Ⅴ级分别为2例、8例、10例、6例、4例,总有效率为93.33%(28/30),两组患者差异无统计学意义(P>0.05);两组患者治疗后血管瘤血流峰值及阻力系数较治疗前均得到改善(P<0.05),而两组间差异均无统计学意义(P>0.05);不良反应情况,除观察组发生3例涂抹部位发红外,两组患者均未发生严重不良反应。结论采用盐酸普萘洛尔凝胶外涂治疗婴幼儿浅表性血管瘤疗效显著,安全可靠,临床上值得进一步推广。

关键词: 盐酸普萘洛尔凝胶, 婴幼儿, 浅表性血管瘤

Abstract: Objective To evaluate the efficacy and safety of Propranolol hydrochloride gel in the external application treatment of superficial hemangioma in infants. Methods We selected 60 infants with superficial hemangioma treated in our hospital from May 2015 to May 2017 and to randomly divide them into the observation group and the control group, each with 30 cases. The control group was treated with Propranolol hydrochloride tablets, and the observation group was treated with 0.5% (20 g∶100 mg) Propranolol hydrochloride gel external application method, the course of treatment was 3 months.We observed the therapeutic effects and adverse reactions of the two groups. Results After treatment, with the Achauer evaluation, patients with grade Ⅰ had 1 case, grade Ⅱ 6 cases, grade Ⅲ 12 cases, grade Ⅳ 8 cases, Ⅴ-grade 3 cases, and the total effective rate was 96.67% (29/30), while the grade Ⅰ, Ⅱ, Ⅲ, Ⅳ, Ⅴ in the control group included 2 cases, 8 cases, 10 cases, 6 cases, 4 cases, and the total effective rate was 93.33% (28/30), there was no significant difference between the two groups (P>0.05); The hemangioma peak flow and resistance coefficient of patients in the two groups were significantly improved than that before the treatment (P<0.05), and all with no statistically significant difference between the two groups (P>0.05). As to the adverse reactions, except the applying parts of 3 cases having rubefaction occurred in the observation group, two groups of patients had no serious adverse reactions. Conclusion External application of Propranolol hydrochloride gel in the treatment of superficial hemangioma in infants is effective, safe and reliable. It is worthy of further promotion in clinic.

Key words: Propranolol hydrochloride gel, Infant, Superficial hemangioma

朱婉灵, 谭淑娟. 盐酸普萘洛尔凝胶外涂治疗婴幼儿浅表性血管瘤的疗效及安全性[J]. 广州医药, 2017, 48(6): 40-42.

ZHU Wanling, TAN Shujuan. Efficacy and safety of Propranolol hydrochloride gel in the external application treatment on superficial hemangioma in infants[J]. Guangzhou Medical Journal, 2017, 48(6): 40-42.

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盐酸普萘洛尔凝胶外涂治疗婴幼儿浅表性血管瘤的疗效及安全性

Efficacy and safety of Propranolol hydrochloride gel in the external application treatment on superficial hemangioma in infants

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